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© 1993 Oxford University Press

research-article

A Two-Generation Reproduction Study with Hydroquinone in Rats1,2

A. M. BLACKER*,3, R. E. SCHROEDER{dagger}, J. C. ENGLISH{ddagger}, S. J. MURPHY§, W. J. KRASAVAGE{ddagger} and G. S. SIMON*

*Rhône-Poulenc Inc. P.O. Box 12014, Research Triangle Park, North Carolina 27709 {dagger}Pharmaco-LSR East Millstone, New Jersey {ddagger}Eastman Kodak Company Rochester, New York §The Goodyear Tire & Rubber Company Akron, Ohio

Received February 1, 1993; accepted June 23, 1993

A Two-Generation Reproduction Study with Hydroquinone in Rats. BLACKER, A. M., SCHROEDER, R. E., ENGLISH, J. C., MURPHY, S. J., KRASAVAGE, W. J., AND SIMON, G. S. (1993). Fundam. Appl. Toxicol. 21, 420–424.

The effects of hydroquinone (HQ) on reproductive performance and fertility were assessed in a two-generation study with CD Sprague-Dawley rats (one litter per generation). HQ was administered in an aqueous solution by gavage at doses of 0, 15, 50, and 150 mg/kg/day. F0 and F1 parental animals were dosed daily for at least 10 weeks prior to cohabitation, during cohabitation, and until scheduled termination. At all dose levels tested, no adverse effects were observed on feed consumption, survival, or reproductive parameters for the F0 or F1 parental animals. Mild, transient tremors were observed shortly after dosing at 150 mg/kg/day in several F0 and F1 parental animals and in a single F0 male at 50 mg/kg/day. These tremors occurred infrequently and were considered to be due to an acute stimulatory effect of HQ on the nervous system. Body weights for F0 and F1 parental females were similar between all dose groups throughout the study. Body weights for F0 parental males were also comparable to those of control throughout the study. Statistically significant differences in body weights were noted for the F1 parental males in the 50 and 150 mg/kg/day dose groups at several intervals during the premating, mating, and postmating periods. No treatment-related effects on pup weight, sex distribution, or survival were noted for pups of either generation. Upon postmortem examination, no treatment-related gross lesions were observed in either the F0 or F1 parental animals or their weanlings. Histopathologic examination of reproductive tissues and pituitary glands from high-dose F0 and F1 parental animals did not reveal any changes related to treatment with HQ. Thus, no adverse effects on reproduction or fertility were observed in either generation at any dose level, and the results of the present study indicate that HQ is not a selective reproductive toxicant. The no observed effect levels for general and reproductive toxicity are 15 and 150 mg/kg/day, respectively.


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