Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by GOLDSWORTHY, T. L.
Right arrow Articles by PURCHASE, I.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GOLDSWORTHY, T. L.
Right arrow Articles by PURCHASE, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 Oxford University Press

review-article

Transgenic Animals in Toxicology1

THOMAS L. GOLDSWORTHY*, LESLIE REICO*, KEN BROWN{dagger}, LAWRENCE A. DONEHOWER{ddagger}, JON C. MIRSALIS§, RAYMOND W. TENNANT|| and IN PURCHASE

*Chemical Industry Institute of Toxicology, Six Davis Drive P.O. Box 12137, Research Triangle Park, North Carolina 27709 {dagger}Beatson Institute for Cancer Research Garseube Estate, Switchback Road, Bearsden, Glasgow G61 IBD, Scotland {ddagger}Division of Molecular Virology, Baylor College of Medicine I Baylor Place, Houston. Texas 77030 §SRI International, 333 Ravenswood Avenue Menlo Park, california 94025-3493 ||National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709 ¶Zeneca Central Toxicology Laboratory, Alderly Park Macclesfield, Cheshire, SKIO 4TJ United Kingdom

Received August 20, 1993; accepted August 25, 1993

Recent advances have been made in the characterization of a number of transgenic animal models. These animal models have provided a powerful toxicological tool for studying in vivo chemical effects and have increased our understanding of the role of specific genetic alterations as predisposing factors for chemical carcinogenesis. The goal of this symposium was to introduce the development of transgenic animals and the utilization of trans genies in toxicology research focusing on understanding tissue- specific mutation, chemical effects, and cancer. The production of transgenic animals, including gene insertions and gene knockouts, and the utilization of transgenic technology for studying multistage carcinogenesis and tumor suppressor genes are described. Data on the application and implications of transgenics as a genetic endpoint are also discussed. The use of transgenic animals in toxicology should improve our understanding of the role of specific genetic alterations in the carcinogenic process and lead to improved estimations of human health risks.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.