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© 1983 Oxford University Press

research-article

A Biomicroscopic Method for Quantitation of Ocular and Adnexal Toxicity

ROXY A. BARNETTA and SAMUEL B. ARONSONB

AThe Clorox Company Oakland, CA 94566 BThe Eyetis Foundation, San Francisco CA 94115

A Biomicroscopic Method for Quantitation of Ocular and Adnexal Toxicity. Barnett, Roxy A. and Aronson, Samuel B. (1983). Fundam. Appl. Toxicol. 3:187-191. A biomicroscopic method for evaluation of ocular and adnexal toxicity in the white rabbit has been developed. When compared to the Draize method, the biomicroscopic method demonstrates a greater spectrum of clinical signs allowing for better dose-response characteristics. This method was found to be both reproducible and easy to execute. The biomicroscopic method, by defining discrete anatomical entities, allows for a high degree of predictability as to severity of ocular and adnexal toxicity as well as the occurrence of permanent ocular injury.


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