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© 1983 Oxford University Press

research-article

Metabolic Disposition of Pyrithiones*

C. MITOMA, T. STEEGER, J. ROGERS, D. THOMAS and J.H. WEDICA

SRI International Menio Park, CA AOlin Corporation New Haven, CT

Metabolic Disposition of Pyrithiones. Mitoma, C., Steeger, TM Rogers, J., Thomas, DM and Wedig, J.H. (1983). Fundam, Appl. ToxicoL 3: 256–263. The urinary pattern of pyri-thione metabolites in urine of the rat, rabbit and rhesus monkey was similar to that of the swine after iv. administration of sodium pyrithione (Sodium Omadine®) and the magnesium sulfateadduct of 2, 2'-dithio-bis(pyridine-l-oxide), (Omadine® MDS). The major metabolite accounting for 80% or more of the metabolites in urine was the S-glucuronide of 2-mercaptopyridine-N-oxide. After Omadine® MDS administration, three transient metabolites and one persistent metabolite were observed in the plasma. The transient metabolites were tentatively identified as 2-methylthiopyridine-N-oxide, 2-methylsulfinylpyridine and 2-methylsulfinyl-pyridine-N-oxide. 2-Methylsulfonylpyridine was the only metabolite observed in the plasma 16 hr after Omadine® administration. This metabolite could be detected 14 days after rats were treated repeatedly with a shampoo formulation containing Omadine MDS.


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