© 1983 Oxford University Press
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Effects of Sulfur Dioxide and Ozone on Hypertension Sensitive and Resistant Rats
Medical Department, Brookhaven National Laboratory Upton, NY 11973
Effects of Sulfur Dioxide and Ozone on Hypertension Sensitive and Resistant Rats. Drew, R.T., Kutzman, R.S., Costa, D.L., and Iwai, J. (1983). Fundam. Appl Toxicol 3: 298–302. Two lines of Dahl rats, one resistant to salt-induced hypertension (DR) and one susceptible to salt-induced hypertension (DS) were subchronically exposed to SO2 (50 ppm, 6 hr/d, 5 d/wk for 31 weeks) or ozone (2.0 ppm, 6 hr/d, 5 d/wk for 20 weeks). Subgroups of rats were maintained on either high or low salt diets. In rats not expected to develop hypertension, exposure to SO2 caused a slight but consistent decrease in blood pressure. In DS rats on a high salt diet exposure to SO2 resulted in an increase in blood pressure over that of their air exposed counterparts. All exposure-related differences in blood pressure disappeared after the last exposure to SO2. Exposure to ozone was fatal to all DS rats, regardless of the amount of salt in the diet. The DR rats were more resistant to ozone, with most animals surviving the 20-week exposure. Ozone-exposed rats exhibited a decrease in both growth rate and blood pressure in all groups when compared to their air-exposed counterparts. It is not known if exposure-related blood pressure differences would persist after ending ozone exposures. After brief exposures, ozone caused increased lung weights in both groups, but there were no consistent changes in pulmonary nonprotein sulfhydryl groups. Hepatic nonpro-tein sulfhydryl levels were consistently, but not significantly, lower in ozone-exposed rats.