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© 1983 Oxford University Press

other

n-Butyl Acrylate: Cytogenetic Investigations in the Bone Marrow of Chinese Hamsters and Rats After 4-Day Inhalation

G. ENGELHARDT and H.-J. KLIMISCH

Department of Toxicology of BASF Aktiengesellschaft D-6700 Ludwigshafen, FRG

n-Butyl Acrylate: Cytogenetic Investigations in the Bone Marrow of Chinese Hamsters and Rats After 4-Day Inhalation. Engelhardt, G. and Klimisch, H.-J. (1983). Fundam. Appl. Toxicol 3:640–641. Chinese hamsters and rats were exposed to an average concentration of 817 ppm and 820 ppm n-butyl acrylate (acrylic acid n-butyl ester), respectively for 4 days. In both animal species, the exposure led to distinct signs of toxicity; four often male Chinese hamsters died during the exposure period. The chromosome analysis carried out in the bone marrow of the animals after the 4-day inhalation did not indicate any chromosome-damaging effect of n-butyl acrylate. Under the experimental conditions chosen the percentage of metaphases damaged was always in the same range as that of the controls for both Chinese hamsters and rats.


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