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© 1996 Oxford University Press

other

National Toxicology Program Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment

J. R. BUCHER1, C. J. PORTIER, J. I. GOODMAN*, E. M. FAUSTMAN{dagger} and G. W. LUCIER

National Institute of Environmental Health Sciences, Research Triangle Park North Carolina 27709 *Department of Pharmacology, Michigan State University East Lansing, Michigan 48824 {dagger}Department of Environmental Health, University of Washington Seattle, Washington 98195

Received November 13, 1995; accepted December 8, 1995

A workshop entitled "NTP Studies: Principles of Dose Selection and Applications to Mechanistic Based Risk Assessment" was held at the 34th Annual Meeting of the Society of Toxicology in Baltimore, Maryland. The purpose of the workshop was to provide an overview of factors currently considered important in the selection of doses for NTP studies, to describe some of the confounding factors that can result from the indiscriminate use of bioassay data in quantitative risk assessment, and to suggest ways in which information from mechanistic studies or studies of biomarkers of exposure or effect might be used to better advantage in risk assessment.


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