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© 1996 Oxford University Press

research-article

Testicular Toxicity of Gallium Arsenide, Indium Arsenide, and Arsenic Oxide in Rats by Repetitive Intratracheal Instillation

MINORU OMURA*, AKIYO TANAKA*, MIYUKI HIRATA*, MANGEN ZHAO*, YUJI MAKITA*, NAOHIDE INOUE*, KAORU GOTOH{dagger} and NOBURU ISHINISHI{ddagger}

*Department of Hygiene, Faculty of Medicine, Kyushu University Fukuoka, Japan {dagger}Department of Inhalation Test Section, Division of Experimental Toxicology, Japan Industrial Safety and Health Association Fukuoka, Japan {ddagger}Department of Nakamura Gakuen College Fukuoka, Japan

Received November 2, 1995; accepted March 14, 1996

The testicular toxicities of two compound semiconductor materials, gallium arsenide (GaAs) and indium arsenide (InAs), and arsenic oxide (As2O3) were examined in rats by repetitive intratracheal instillation of these substances in suspension twice a week, a total of 16 times. A single instillation dose was 7.7 mg/kg in the GaAs and the InAs groups and 1.3 mg/kg in the As2O3 group. A significant decrease in sperm count and significant increase in the proportion of morphologically abnormal sperm were found in the epididymis in the GaAs group. Especially, abnormal sperm with a straight head increased markedly in this group. In the GaAs–treated rats, there was 40-fold increase in the degenerating late elongated spermatids at the postspermiation stages, stages IX, XI, and XI. From these results, it is indicated that GaAs disturbed the spermatid head transformation at the late spermiogenic phases and caused spermiation failure. InAs caused a sperm count decrease in the epididymis, though its testicular toxicity was relatively weak compared with that of GaAs. As2O3, a probable dissolution arsenic product of GaAs and InAs in vivo, did not show any testicular toxicities in this study. It seems likely that, along with arsenics, gallium and indium play a role in the testicular toxicities of GaAs and InAs.


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