Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by REEL, J. R.
Right arrow Articles by NEAL, B. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by REEL, J. R.
Right arrow Articles by NEAL, B. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1996 Oxford University Press

other

Survey and Assessment of Mammalian Estrogen Biological Assays for Hazard Characterization

JERRY R. REEL*, JAMES C. LAMB, IV{dagger} and BARBARA H. NEAL{dagger}

*BIOQUAL, Incorporated, 9600 Medical Center Drive Rockville, Maryland 20850-3300 {dagger}Jellinek, Schwartz, & Connolly, Inc. 1525 Wilson Boulevard, Suite 600, Arlington, Virginia 22209

Received April 11, 1996; accepted August 13, 1996

With the growing awareness and concern regarding estrogens in the environment, the selection of reliable and appropriate methods for their detection and characterization has taken on considerable importance. The relevant literature covering the period from 1920 to 1996 was surveyed to identify methods that have been used to assay estrogens in mammalian systems. The estrogen biological assays identified were grouped into four categories: (1) reproductive tract response; (2) non-reproductive-tract target tissue response; (3) estrogen receptor binding; and (4) estrogen receptor-dependent transcriptional expression. The biological assays were summarized and their advantages and disadvantages discussed. A possible testing scheme also was provided to characterize estrogens, anti-estrogens, and pro-estrogens (chemicals metabolically converted to estrogens).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.