© 1984 Oxford University Press
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Absorption, Distribution, Metabolism, and Excretion of 1,3-Diphenylguanidine in the Male F344 Rat1
Toxicology Research and Testing Program, National Institute of Environmental Health Sciences P.O. Box 12233, Research Triangle Park, North Carolina 27709
Absorption, Distribution, Metabolism, and Excretion of 1,3-Diphenylguanidine in the Male F344 Rat IOANNOU, Y. M., AND MATTHEWS, H. B. (1984). Fundam. Appl. Toxicol. 4, 22-29. 1,3-Diphenylguanidine (DPG), a rubber accelerator, was readily absorbed from the gastrointestinal tract of the male Fischer rat and rapidly distributed throughout the body tissues. Absorption and disposition of DPG were not significantly affected by the route of administration or by the dose in the dose range studied, 1.5 to 150 µmol/kg. Most of the dose of DPG was excreted in the urine and feces at approximately equal amounts within 24 hr after oral or iv administration. Greater than 99% of the DPG dose was cleared into the urine and feces within 3 days after administration. Approximately 30% of the DPG-derived radioactivity excreted in urine was the parent compound, DPG, while the remainder was present in the form of two major and one minor metabolite. Close to 95% of the radioactivity excreted in bile was in the form of a single major metabolite. Administration of multiple doses resulted in a proportional increase of DPG-derived radioactivity in the liver as the number of doses increased. DPG-derived radioactivity did not increase in other tissues following multiple doses.