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© 1984 Oxford University Press

research-article

Teratologic Evaluation of 3,6-Dichloropicolinic Acid in Rats and Rabbits

W. C. HAYES, F. A. SMITH, J. A. JOHN and K. S. RAO

The Dow Chemical Company. H&ES, U.S.A., Toxicology Research Laboratory 1803 Building, Midland, Michigan 48640

Teratologic Evaluation of 3,6-Dichloropicolinic Acid in Rats and Rabbits. HAYES, W. C, SMITH, F. A., JOHN, J. A., AND RAO, K. S., (1984). Fundam, Appl. Toxicol. 4, 91–97. 3,6-Dichloropicolinic acid (clopyralid), a new herbicide, was evaluated for teratogenic potential in Fischer 344 rats and New Zealand White rabbits. Rats were given 0, 15, 75, or 250 mg clopyralid/kg/day by gavage on Days 6–15 of gestation while rabbits were given 0, 110, or 250 mg clopyralid/kg/day on Days 6–18 of gestation. Maternal toxicity, as evidenced by decreased body weight gain, was observed among pregnant rats in the 250-mg/kg/day group. No evidence of maternal toxicity was observed among treated rabbits. A teratogenic effect was not detected in either species.


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