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© 1984 Oxford University Press

research-article

Mechanisms of Toxicological Interactions Involving Organophosphate Insecticides1

STEVEN D. COHEN

Toxicology Program, Section of Pharmacology and Toxicology, University of Connecticut, School of Pharmacy Storrs, Connecticut 06268

Mechanisms of Toxicological Interactions Involving Organophosphate Insecticides. COHEN, S. D. (1984). Fundam. Appl. Toxicol. 4, 315–324. Administration of apparently nontoxic doses of organophosphorus compounds can greatly alter the toxicity of other compounds. These might include other organophosphates, as well as other drug or nondrug xenobiotics. Mechanisms of toxicologic interactions are discussed. Emphasis is placed upon organophosphate inhibition of noncritical tissue esterases and alterations in the metabolism and toxicity of selected ester and amide containing xenobiotics.


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