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© 1984 Oxford University Press

research-article

Modulation of Chemical Carcinogenesis by Xenobiotics1

GARY M. WILLIAMS

American Health Foundation, Naylor Dana Institute for Disease Prevention Dana Road, Valhalla, New York 10595

Modulation of Chemical Carcinogenesis by Xenobiotics. WILLIAMS, G. M. (1984). Fundam. Appl. Taxicol. 4, 325–344. Xenobiotics enhance and inhibit chemical carcinogenesis by a variety of mechanisms through effects at different steps in the overall process, including modification of carcinogen availability, biotransformation, reactive interactions, expression of cellular alteration, and neoplastic development. Importantly, the same agent can be both an enhancer or an inhibitor depending upon the circumstance of its interaction with the carcinogen.


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