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© 1984 Oxford University Press

research-article

Concentration and Particle Size Distribution in Smoke from Marijuana Cigarettes with Different {Delta}9-Tetrahydrocannabinol Content1

F. CHARLES HILLER*,2, FRANK J. WILSON, JR.*, MALAY K. MAZUMDER{dagger}, J. DOUGLAS WILSON{dagger} and ROGER C. BONE*

*Pulmonary Division and Division of Interdisciplinary Toxicology, University of Arkansas College of Medicine Little Rock, Arkansas 72205 {dagger}Department of Electronics and Instrumentation, Graduate Institute of Technology Little Rock, Arkansas 72203

Concentration and Particle Size Distribution in Smoke from Marijuana Cigarettes with Different {Delta}9-Tetrahydrocannabinol Content. HILLER, F. G., WILSON, F. J., JR., MAZUMDER, M. K., WILSON, J. D., AND BONE, R. C. (1984). Fundam. Appl. Toxicol. 4, 451–454. Particle size and mass concentration are important determinants of site and quantity of respiratory tract deposition of aerosols. Particle concentrations and size distributions of smoke from marijuana cigarettes with different concentrations (as measured in the marijuana leaf) of {Delta}9-tetrahydrocannabinol ({Delta}9-THC) were measured using a single particle aerodynamic relaxation time (SPART) analyzer. The SPART analyzer measures aerodynamic diameter of single suspended particles at a rate of 3000/min. Cigarettes were smoked using a 35-cc, 2-sec puffing device attached to a diluter, dilution and analysis were completed within 4 sec of puff generation. The size distribution of smoke from all marijuana cigarettes was similar to that for tobacco cigarettes, ranging from 0.35 to 0.43 µm (count median aerodynamic diameter). The particle number and mass concentration increased as {Delta}9-THC concentration increased, being, respectively, 2.2- and 3.8-fold higher in the marijuana cigarette leaf with highest {Delta}9-THC concentration compared to the placebo marijuana cigarette. These data indicate the need for quantitative comparisons of other potentially toxic constituents in marijuana cigarettes of different {Delta}9-THC concentrations.


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