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© 1984 Oxford University Press

research-article

Pyrithione: Plasma Metabolite in Man

J. H. WEDIG, S. J. BARBEE and C. MITOMA*

*SRI International Menlo Park California Olin Corporation, New Haven Connecticut 06511

Pyrithione: Plasma Metabolite in Man. WEDIG, J. H., BARBEE, S. J., AND MITOMA, C. (1984). Fundam. Appl. Toxicol. 4, 497–498. 2-Methylsulfonylpyridine (2-MSP) has been identified as the terminal plasma pyrithione metabolite in rats, rabbits, dogs, and monkeys (W. B. Gibson, A. R. Jeffcoat, P. D. Rodriguez, T. S. Turan, P. F. Hughes, and M. E. Twine, Toxicol. Appl. Pharmacol. 62, 237–250 (1982); C. Mitoma, T. Steeger, J. Rogers, D. Thomas, and J. H. Wedig, Fundam. Appl Toxicol. 3, 256–263 (1983)). This metabolite was detected in the systemic circulation of humans involved in the chemical manufacturing process. This confirms that the terminal pyrithione metabolite in plasma is identical among rat, rabbit, dog, monkey, and man.


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