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© 1984 Oxford University Press

research-article

Effects of Inhaled HF on Lipid Metabolism in Guinea Pigs

J. C. DOUSSET*,{ddagger}, C. RIOUFOL{dagger}, R. FELISTE{dagger}, P. LÉVY{ddagger} and P. BOURBON{dagger},{ddagger}

*Laboratoire de Biochimie, Faculté de Pharmacie 31 allées Jules Guesde 31000 Toulouse {dagger}Laboraloire de Toxicologie, Facullé de Pharmacie 31 allees Jules Guesde, 31000 Toulouse {ddagger}INSERM U.57. allée Camille Soula 31320 Vigoulet-Auzil, France

Effects of Inhaled HF on lipid Metabolism in Guinea Pigs. Dousset, J. C, Rioufol, C, Feuste, R., Lévy, P., and Bourbon, P. (1984). Fundam. Appl. Toxicol. 4, 618–623. Guinea pigs were exposed to hydrogen fluoride (10 mg/m3) for 84 hr. Plasma triglyceride and cholesterol levels were significantly increased in the treated animals with respect to the controls. An increase in triglyceride levels was also observed in the liver. The metabolism of plasma and hepatic lipids was studied using incorporation of [1-l4C]acetate. Compared to the control group, triglyceride synthesis was accelerated in the liver of the fluoride group. Extrahepatic lipoprotein lipase activity however was decreased in the fluoride group; this could be related to the decrease in apoprotein C.


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