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© 1984 Oxford University Press

research-article

Exploration of the Negative Correlation between Proliferative Hepatocellular Lesions and Lymphoma in Rats and Mice—Establishment and Implications

S. STANLEY YOUNG and CHRISTIAN L. GRIES

Statistical and Mathematical Services, Department of Pathology, Lilly Research Laboratories, A Division of Eli Lilly and Company P.O. Box 708, Greenfield, Indiana 46140

Exploration of the Negative Correlation between Proliferative Hepatocellular Lesions and Lymphoma in Rats and Mice—Establishment and Implications. YOUNG, S. S., AND GRIES, C. L. (1984). Fundam. Appl. Toxicol. 4,632–640. Data from 1858 mice at Lilly and eight studies from the literature were used to establish a negative correlation between proliferative hepatic lesions and malignant lymphoma in rodents. This negative correlation implies that the rodent model is flawed in the sense that interpretation of hepatic lesions without consideration of malignant lymphoma can lead to the incorrect conclusion that there is something unique about the compound. In fact it is the rodent model that has a unique feature—the negative correlation.


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