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© 1984 Oxford University Press

research-article

Application of an in Vitro Keratinization Assay to Extracts of Soot from a Fire in a Polychlorinated Biphenyl-Containing Transformer1

JOHN F. GIERTHY, DEBORAH CRANE and GERALD D. FRENKEL

Wadsworth Center for Laboratories and Research, New York State Department of Health Albany, New York 12201

Application of an in Vitro Keratinization Assay to Extracts of Soot from a Fire in a Polychlorinated Biphenyl-Containing Transformer. Gierthy, J. F., CRANE, D., AND FRENKEL, G. D. (1984). Fundam. Appl. Toxicol. 4, 1036–1041. A fire in the State Office Building in Binghamton, New York, involving a polychlorinated biphenyl-containing electrical transformer, resulted in contamination of the structure with soot containing 2,3,7,8-tetrachlorodibenzo-P-dioxin and 2,3,7,8-tetrachlorodibenzofuran. Benzene extracts of soot collected from various areas of the building were tested for in vitro keratinization-inducing activity by the method of J. C. Knutson and A. Poland (Cell 22, 27–36, 1980). The results, in terms of relative keratinization-inducing activity, are compared to a high-resolution gas chromatographic/mass spectrometric analysis for total polychlorinated dibenzofurans in the same samples. This comparison showed a good correlation and suggests that the in vitro keratinization model has potential for use as a semiquantitative assay for dioxinlike activity.


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