Toxicological Sciences, Vol 52, 45-49, Copyright © 1999 by Society of Toxicology
AM Cummings, JM Hedge and LS Birnbaum
Several lines of research led to our hypothesis that perinatal exposure to
TCDD may alter the sensitivity of adult rodents to the promotional effect
of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on endometriosis. Pregnant
rats and mice were treated on gestation day (GD) 8 with either 1 (rats) or
3 (mice) microg TCDD/kg or vehicle. Female offspring were reared to
adulthood, and endometriosis was induced surgically. All animals received
0, 3, or 10 microg TCDD/kg 3 weeks prior to surgery, at the time of
surgery, and 3, 6, and 9 weeks after surgery. Necropsies were performed 12
weeks after surgery. Measurements at necropsy included the diameter of
endometriotic lesions and body, uterine, ovarian and liver weights. While
no effect of treatment on lesion diameter was found in rats, analyses
revealed that perinatal plus adult exposure to TCDD can increase the size
of endometriotic lesions surgically induced in mice. These and additional
data on body and organ weights are consistent with previous work. These
data confirm the sensitivity of mice to the promotion of endometriotic
lesion growth by TCDD and indicate a perinatal effect of TCDD on this
parameter when perinatal exposure on GD8 is supplemented with adult
exposure to TCDD of female mice.
ARTICLES
Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice
Reproductive Toxicology Division, MD-72, NHEERL, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. cummings.audrey@epamail.epa.gov
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