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Toxicological Sciences 53, 392-399 (2000)
Copyright © 2000 by the Society of Toxicology

Effects of Prenatal Aflatoxin B1 Exposure on Behaviors of Rat Offspring

Takahide Kihara*,1, Takuya Matsuo*, Michiko Sakamoto*, Yoshiko Yasuda*, Yoshitame Yamamoto{dagger} and Takashi Tanimura{ddagger}

* First Department of Anatomy, Kinki University School of Medicine and {ddagger} Life Science Research Laboratory, Kinki University, Osakasayama, Osaka, 589-8511, Japan; and {dagger} Medical Information Department, Santen Pharmaceutical Co. Ltd., Higashiyodogawa-ku, Osaka, 533-0021, Japan

The effects of prenatal aflatoxin B1 (AFB) exposure on eight behavioral parameters in Jcl:Wistar rat offspring were assessed. Pregnant rats were injected subcutaneously with 0.3 mg/kg/day of AFB dissolved in dimethylsulfoxide on days 11–14 (Group A) or 15–18 (Group B) of gestation. Controls received the vehicle similarly on days 11–18 of gestation. Before weaning, the offspring were examined using the cliff avoidance response (5 days of age), the negative geotaxis reflex (7 days), and swimming development (6, 8, and 10 days). After weaning, animals were examined using the rotarod test (5 weeks of age), the open field test (6 weeks), a conditioned avoidance learning test (14 weeks), an underwater T-maze test (15 weeks), and a reproduction test (16 weeks). The preweaning offspring in the AFB-A group showed significantly lower success rates than controls in cliff avoidance responses. In swimming development, the offspring in the AFB-A group had significantly lower scores than controls for swimming direction. In the rotarod test, the AFB-A group remained on the rod for a significantly shorter time than the controls at 15 rpm on both the first and second trial days. The avoidance performance of the rats in AFB-A and AFB -B groups was significantly poorer than that of controls. These results indicate that prenatal exposure to AFB produced a delay of early response development, impaired locomotor coordination, and impaired learning ability in the offspring of rats exposed to AFB during middle pregnancy, and the early gestational exposure appears to produce more effects than latter exposure.

Key Words: aflatoxin B1; 2,3,6a{alpha},9a{alpha}-tetrahydro-4-methoxycyclopenta[c]furo[3',2',: 4,5]furo[2, 3-h][1] benzopyran-1, 11-dione; mycotoxin; behavioral teratology; prenatal exposure; developmental toxicity; neurotoxicity.


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