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Toxicological Sciences 56, 437-438 (2000)
Copyright © 2000 by the Society of Toxicology

Letters to the Editor

Paul H. Dugard

Halogenated Solvents Industry Alliance 2001 L Street NW, Suite 506A Washington, DC 20036

To the Editor:

Boyer et al. (2000) report effects of trichloroethylene (TCE) on an in vitro chick atrioventricular canal culture as a method for investigating the induction of cardiac defects. Unfortunately the authors have overlooked factors that should always be considered when employing in vitro techniques. One such factor is the physical chemistry of the test agent in the incubation medium; another is the relationship between the in vitro conditions and those found in whole animal experiments or during human exposures.

The solubility of TCE in water is 1.366 g/l, or 1,366 ppm at 25°C (McNeill, 1979Go). Solubility will be slightly higher . . . [Full Text of this Article]

REFERENCES

Raymond Runyan

Dept. of Cell Biology and Anatomy University of Arizona P.O. Box 245044 1501 N. Campbell Ave.,LSN 462 Tucson, AZ 85724-5044




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P. T. Caldwell, P. A. Thorne, P. D. Johnson, S. Boitano, R. B. Runyan, and O. Selmin
Trichloroethylene Disrupts Cardiac Gene Expression and Calcium Homeostasis in Rat Myocytes
Toxicol. Sci., July 1, 2008; 104(1): 135 - 143.
[Abstract] [Full Text] [PDF]