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Toxicological Sciences 58, 416-417 (2000)
Copyright © 2000 by the Society of Toxicology


Letters to the Editor

Letter

Stanton A. Glantz and William W. Parmely

Division of Cardiology, University of California, San Francisco, CA 94143-0130

To the Editor:

Smith et al. (2000) recently published a paper countering the hypothesis that secondhand smoke activates platelets. They stated that this effect, which would at least partially explain the high sensitivity of nonsmokers to secondhand smoke in terms of heart disease risk, could not be correct based on dose-response considerations. Their arguments, based on dose-response curves, ignore the fact that secondhand smoke does not appear to have an effect on platelet activity in smokers (whose platelets are already highly activated). This indicates that the underlying process involves either a different process in nonsmokers (who . . . [Full Text of this Article]

REFERENCES

Carr J. Smith, Stephen B. Sears and Thomas H. Fischer

Research and Development Department Bowman Gray Technical Center R.J. Reynolds Tobacco Company Winston-Salem, NC 27102 University of North Carolina at Chapel Hill School of Medicine Department of Pathology (FOBRL) 350 South Old Fayetteville Road Chapel Hill, NC 27516


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