Toxicological Sciences 59, 147-159 (2001)
Copyright © 2001 by the Society of Toxicology
Reproductive and Developmental Toxicology |
Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis
* Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756;
Centers for Disease Control, U.S. Public Health Service, Atlanta, Georgia 30341;
Department of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee 38103; and
§ National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with a dose-dependent increase in the incidence and severity of endometriosis in the rhesus monkey. Dioxin-like chemicals can also exert effects in combination with TCDD via the aryl hydrocarbon receptor. This study demonstrates that the serum levels of TCDD and specific dioxin-like PHAH congeners were increased in TCDD-treated animals with endometriosis 13 years after the TCDD exposure. Nine TCDD-exposed and 6 unexposed female rhesus monkeys were evaluated for serum content of relevant compounds and for endometriosis by surgical laparoscopy. Additional studies were done on 4 animals that died 7 to 11 years after exposure to TCDD and 4 lead-treated animals with no history of PHAH treatment. For TCDD-exposed and unexposed animals, TCDD exposure correlated with an increased serum TCDD concentration. Furthermore, TCDD exposure and an elevated serum TCDD concentration were associated with increased serum levels of triglycerides, 1,2,3,6,7,8-hexachlorodibenzofuran, 3,3',4,4'-tetrachlorobiphenyl (TCB) and 3,3'4,4',5-pentachlorobiphenyl (PnCB). Importantly, the animals with elevated serum levels of 3,3',4,4'-TCB, 3,3',4,4',5-PnCB and an increased total serum TEQ had a high prevalence of endometriosis, and the severity of disease correlated with the serum concentration of 3,3,',4,4'-TCB. Increased serum concentrations of coplanar PCBs were also present in lead-treated animals. Implications of these findings for human health and the prevalence of endometriosis in humans will be discussed.
Key Words: endometriosis; rhesus monkey; environmental toxicants; dioxin; TCDD; PCB; dioxin-like chemicals.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. W. Montgomery, D. R. Nyholt, Z. Z. Zhao, S. A. Treloar, J. N. Painter, S. A. Missmer, S. H. Kennedy, and K. T. Zondervan The search for genes contributing to endometriosis risk Hum. Reprod. Update, June 5, 2008; (2008) dmn016v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Caserta, L. Maranghi, A. Mantovani, R. Marci, F. Maranghi, and M. Moscarini Impact of endocrine disruptor chemicals in gynaecology Hum. Reprod. Update, January 1, 2008; 14(1): 59 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yoshizawa, A. Heatherly, D. E. Malarkey, N. J. Walker, and A. Nyska A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF Toxicol Pathol, December 1, 2007; 35(7): 865 - 879. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Rier and W. G. Foster Environmental Dioxins and Endometriosis Toxicol. Sci., December 1, 2002; 70(2): 161 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. RIER The Potential Role of Exposure to Environmental Toxicants in the Pathophysiology of Endometriosis Ann. N.Y. Acad. Sci., March 1, 2002; 955(1): 201 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. FOSTER and S. K. AGARWAL Environmental Contaminants and Dietary Factors in Endometriosis Ann. N.Y. Acad. Sci., March 1, 2002; 955(1): 213 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Bofinger, L. Feng, L.-H. Chi, J. Love, F. D. Stephen, T. R. Sutter, K. G. Osteen, T. G. Costich, R. E. Batt, S. T. Koury, et al. Effect of TCDD Exposure on CYP1A1 and CYP1B1 Expression in Explant Cultures of Human Endometrium Toxicol. Sci., August 1, 2001; 62(2): 299 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Rier, C. L. Coe, A. M. Lemieux, D. C. Martin, R. Morris, G. W. Lucier, and G. C. Clark Increased Tumor Necrosis Factor-{{alpha}} Production by Peripheral Blood Leukocytes from TCDD-Exposed Rhesus Monkeys Toxicol. Sci., April 1, 2001; 60(2): 327 - 337. [Abstract] [Full Text] [PDF]
|
|