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© 1986 Oxford University Press

research-article

Effects of the Organophosphorus Compound, O-ethyl-N-dimethyl phosphoramidocyanidate (Tabun), on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats1,2

JAMES A. ROMANO, JR.*,3 and MICHAEL R. LANDAUER{dagger},4

*US Army Medical Research Institute of Chemical Defense Aberdeen Proving Ground {dagger}US Army Chemical Research and Derelopment Center Aberdeen Proving Ground, Maryland 21010 Department of Pharmacology and and Toxicology, Medical College of Virginia, Virginia Commonwealth University Richmond, Virginia 23298

Effects of the Organophosphorus Compound, O-ethyl-N-dimethyl-phosphoramidocyanidate (Tabun), on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats. ROMANO, J. A., JR., AND LANDAUER M. R. (1986). Fundam. Appl. Toxicol. 6,62–68. An assessment of the behavioral effects of acutely administered anti-cholinesterase compound O-ethyl-N-dimethyl phosphoramidocyanidate (tabun), to male rats was performed in three studies across five dose levels (100–198 µg/kg, sc). Doses of 122 µg/kg or greater produced conditioned flavor aversions. Spontaneous locomotor activity was significantly decreased at doses of 122 µg/kg or greater when compared to vehicle control levels. When administered doses of 168 µg/kg or greater, rats exhibited significant decrements in rotarod performance. In addition, the LD50 of tabun was determined to be 240 µg/kg. Signs of cholinergic intoxication were not apparent until 144 µg/kg tabun or more were given. Behavioral effects were thus obtained at doses that were between 54 and 71% of the LD50.


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