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© 1986 Oxford University Press

other

Evaluation of Drug and Chemical Toxicity with Cell Culture Systems1

JUNE A. BRADLAW

Division of Toxicology. Center for Food Safety and Applied Nutrition, Food and Drug Administration Washington, D C 20204

Evaluation of Drug and Chemical Toxicity with Cell Culture Systems. BRADLAW, J. A. (1986). Fundam. Appl. Toxicol. 6, 598–606. Approaches to the evaluation of drug and other chemical toxicity with mammalian cell culture systems are designed to enhance the predictability of animal models. Identification of toxic agents by in vitro screening tests and studies of mechanisms through which chemicals induce critical lesions at the cellular and subcellular levels help to make those predictions sooner and perhaps single out those target sites and chemicals of most concern.


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