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© 1986 Oxford University Press

research-article

A System for Assessing Toxicity of Chemicals by Continuous Monitoring of Homecage Behaviors1

H. L. EVANS2, P. J. BUSHNELL3, J. D. TAYLOR, A. MONICO, J. J. TEAL4 and M. J. PONTECORVO5

Institute of Environmental Medicine, New York University Medical Center 550 First Avenue, New York, New York 10016

A System for Assessing Toxicity of Chemicals by Continuous Monitoring of Homecage Behaviors. EVANS, H. L., BUSHNELL, P. J., TAYLOR, J. D., MONICO, A., TEAL, J. J., AND PONTE CORVO, M. J. (1986). Fundam. Appl. Toxicol. 6,721–732. A noninvasive system is described for continuous recording of behaviors in the home cages of rats. Commercially available mesh cages reused so as to conform with housing conditions in most toxicological studies. A minicomputcr controlled environmental lighting and recorded eating, drinking, rearing, and horizontal activity. The system's sensitivity was comparable to more complex systems. Validity was demonstrated through manipulation of environmental lighting, food deprivation, and the effects of amphetamine, scopolamine, ethanol, methylscopolamine, triethyltin, and trimethyltin. Advantages over other systems are practicality, economy, the simultaneous analyses of several naturalistic behaviors of individual rats, and the quantification of diurnal rhythms.


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