Toxicological Sciences 68, 267-269 (2002)
Copyright © 2002 by the Society of Toxicology
PROFILES IN TOXICOLOGY |
John Morrison Barnes, 1913–1975
CHE, University of California, One Shields Avenue, Davis, California 95616-8615
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John M. Barnes, the first director of the Toxicology Research Unit of the British Medical Council, was educated as a physician and spent his early years at the Sir William Dunn School of Pathology, University of Oxford.
One day in 1938—as he himself related the story to me and my wife, Christine, in 1966 during a relaxed evening in a Swiss mountain resort—he was approached by a colleague who had developed what looked to be a most promising drug. Before treating people, however, the investigator thought that some toxicity evaluation was in order, and so he asked Barnes to do a few rudimentary tests. Barnes took the compound, injected it intraperitoneally into three mice, found them alive and well the next morning, and reported his findings as "your drug seems not to be toxic." He then was offered to participate in further evaluations of the drug, but declined because, as
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