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Toxicological Sciences 68, 516-517 (2002)
Copyright © 2002 by the Society of Toxicology

Letter

Gerald P. Schoenig, Ph.D.

Toxicology/Regulatory Services, Inc. 2365 Hunters Way Charlottesville, VA 22911 E-mail: trs@toxregserv.com

The first 10% of the full text of this article appears below.

To the Editor:

The article entitled "Locomotor and Sensorimotor Performance Deficit in Rats following Exposure to Pyridostigmine Bromide, DEET, and permethrin, Alone and in Combination," by Abou-Donia et al.(2001) Toxicological Sciences 60, 305–314, describes experiments that were intended to address potential sensorimotor and cholinergic effects of the three chemicals given alone or in combination.

The authors claim that "these results suggest that exposure to physiologically relevant doses of [pyridostigmine bromide] PB, DEET and permethrin, alone or in combination, leads to neurobehavioral deficits and region-specific alterations in AchE and acetylcholine receptors." They also claim that "These results further suggest that exposure with these chemicals, alone or in combination, may have played a role in the development of long-term health consequences associated with the [Persian Gulf War] veterans."

Because of major deficiencies in study design coupled with inappropriate and/or . . . [Full Text of this Article]


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