Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by JOHANNSEN, F. R.
Right arrow Articles by LEVINSKAS, G. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by JOHANNSEN, F. R.
Right arrow Articles by LEVINSKAS, G. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1986 Oxford University Press

research-article

Relationships between Toxicity and Structure of Aliphatic Nitriles1

FREDERICK R. JOHANNSEN and GEORGE J. LEVINSKAS

Monsanto Company, Department of Medicine and Environmental Health 800 N. Lindbergh Blvd., St. Louis, Missouri 63167

Relationships between Toxicity and Structure of Aliphatic Nitriles. JOHANNSEN, F.R., AND LEVINSKAS, G.J. (1986). Fundam. Appl. Toxicol. 7,690-697. A retrospective structure-activity relationship (SAR) comparison was undertaken of several of the toxicological properties (acute and subchronic toxicity, teratogenicity, and biochemical mechanism studies) of a series of structurally similar aliphatic nitriles based on available published data. Members of this chemical class included several mononitriles (aceto-, propio-, butyro-, and acrylonitrile), dinitriles (succi-no- and adiponitrile), and cyanohydrin derivatives (lactonitrile and acetone cyanohydrin). Broadly denned, retrospective SAR analysis suggested that the toxicological profiles of this group of aliphatic nitriles were similar; however, unique differences were observed within each of the toxicity categories and nitrile subclasses as the toxicological focus narrowed. Additionally, the toxicological properties associated with acetonitrile, the first of this chemically similar series, were unique and quite different from others within the homologous series. Finally, knowledge regarding the mechanism of toxicological action provided valuable information in relating toxicological properties among the aliphatic nitriles.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.