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Toxicological Sciences 70, 238-244 (2002)
Copyright © 2002 by the Society of Toxicology

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Effects of Dietary Restriction on Growth, Neurobehavior, and Reproduction in Developing Kunmin Mice

Aiguo Wu*,1, Fada Wan{dagger}, Xiufa Sun{dagger} and Yugu Liu{ddagger}

* Department of Physiological Science, University of California at Los Angeles, Los Angeles, California 90095; {dagger} Department of Nutrition and Food Hygiene and {ddagger} Department of Environmental Toxicology, Tongji Medical University, Wuhan, Hubei 430030, China

The effects of dietary restriction (DR) on growth, neurobehavior, and reproduction in developing Kunmin mice were investigated in this study. Male and female mice were fed a standard rodent diet ad libitum (control), 80% of control (20% DR), or 65% of control (35% DR) for 3 months. Body weight of DR mice was reduced relative to control except that of females in the 20% DR group (no difference as compared with control group). Learning and memory retention test in a Y maze demonstrated that DR increased learning, but not retention, in male mice, whereas neither learning nor retention was affected in females. The open-field test revealed no difference in exploratory activity in all groups. Reproductive assessment showed that 35% DR retarded the maturation of reproductive function and reduced fertility compared with other groups. Furthermore, both 20% and 35% DR led to a lower level of sperm motility and a higher level of abnormal sperm relative to control mice. These findings indicate that DR does not cause damaging effects on growth and neurobehavior, but imposes a risk to reproductive development events.

Key Words: dietary restriction; body weight; reproduction; learning; fertility; sperm; mice.


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