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Toxicological Sciences 71, 282-284 (2003)
Copyright © 2003 by the Society of Toxicology

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Mark Tirmenstein, Catherine Hu, Tracy Gales, Beverly Maleeff, Padma Narayanan, Edit Kurali, Timothy Hart, Heath Thomas and Lester Schwartz

Departments of Safety Assessment and Safety Assessment Statistics, GlaxoSmithKline, King of Prussia, PA 19406

The first 10% of the full text of this article appears below.

To the Editor:

We welcome a chance to respond to the views expressed by Kostrubsky et al. regarding our article. We previously acknowledged that the relevance of our in vitro findings to the idiosyncratic hepatotoxicity of troglitazone (TRO) was uncertain. However, we wish to clarify that the uncertainties as regards findings in HepG2 cells to toxicity observed in patients does not arise from deficiencies in our experiments, but rather reflect the difficulty in extrapolating in vitro data to clinical experiences. We believe our experiments provide very convincing evidence that mitochondrial toxicity is an initiating event in TRO-induced toxicity in HepG2 cells. . . . [Full Text of this Article]


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