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ToxSci Advance Access originally published online on April 15, 2003
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Toxicological Sciences 73, 141-148 (2003)
Copyright © 2003 by the Society of Toxicology

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

André Picard*, Golbahar Palavan{dagger}, Stéphanie Robert{ddagger}, Danielle Pesando{ddagger} and Brigitte Ciapa{dagger},1

* Laboratoire Arago, BP 44, Banyuls sur Mer F-66651 Cedex, France; {dagger} Laboratoire de Biologie du Développement, UMR 7622 CNRS, Université Paris 6, Bât C 5ème étage, Boîte 24, 75252 Paris Cedex 05, France; and {ddagger} Laboratoire Réponses des Organismes aux Stress de l’Environnement, UMR INRA-UNSA 1112, Faculté des Sciences, Parc Valrose, BP 71, 06108 Nice Cedex, France

Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

Key Words: pesticide; methoxychlor; dieldrin; lindane; starfish; mouse; maturation; fertilization; meiosis.


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