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ToxSci Advance Access originally published online on June 27, 2003
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Toxicological Sciences 74, 233-234 (2003)
Copyright © 2003 by the Society of Toxicology

TOXICOLOGICAL HIGHLIGHT

The Tg.AC Mouse Model Passes Test by Failing to Respond

Ronald E. Cannon1

Cancer Biology Group, National Center for Toxicogenomics, NIEHS, Research Triangle Park, North Carolina 27709

ABSTRACT

This issue highlights two companion articles, "Selection of Drugs to Test the Specificity of the Tg.AC Assay by Screening for Induction of the gadd153 Promoter in Vitro" by Karol L. Thompson and Frank D. Sistare (pp. 260–270) and "Evaluation of the Tg.AC Assay: Specificity Testing with Three Noncarcinogenic Pharmaceuticals that Induce Selected Stress Gene Promoters in Vitro and the Inhibitory Effects of Solvent Components" by Karol L. Thompson, Barry A. Rosenzweig, James L. Weaver, Jun Zhang, Karl K. Lin, and Frank D. Sistare (pp. 271–278). These articles outline a unique paradigm for selecting and assaying chemicals for carcinogenic activity using the short-term in vivo Tg.AC mouse model. This Tg.AC mouse model was the primary focus of the work; however, the strategy employed could be exploited for the other alternative mouse models.


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