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ToxSci Advance Access originally published online on June 30, 2004
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Toxicological Sciences 80, 216-217 (2004)
Toxicological Sciences vol. 80 no. 2 © Society of Toxicology 2004; all rights reserved.

TOXICOLOGICAL HIGHLIGHT

Nonlethal Development, Validation, and Application of Cytochrome P4501A1 (CYP1A1) as a Biomarker for Contaminant Exposure

Mark J. Melancon

USGS Patuxent Wildlife Research Center, Beltsville Lab, c/o BARC-East, Building 308, 10300 Baltimore Avenue, Beltsville, Maryland 20705

Received May 6, 2004; accepted May 26, 2004

The first 10% of the full text of this article appears below.

The article highlighted in this issue is "Induction of Cetacean Cytochrome P4501A1 by ß-Naphthoflavone Exposure of Skin Biopsy Slices," by Celine Goddard, Roxanna Smolowitz, Joanna Wilson, Roger Payne, and John Stegeman (pp. 268–275).

The cytochromes P450 (CYPs), particularly the CYP1A family and CYP1A1, have been used as biomarkers of exposure to certain classes of contaminants in both aquatic and terrestrial species.

The types of chemical contaminants that cause induction of the CYP1A family are those that bind to the aryl hydrocarbon receptor (AHR). The classes . . . [Full Text of this Article]


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