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Toxicological Sciences 2004 82(2):361-362; doi:10.1093/toxsci/kfh303
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Toxicological Sciences vol. 82 no. 2 © Society of Toxicology 2004; all rights reserved.

TOXICOLOGICAL HIGHLIGHT

Altered Nuclear Factor Kappa-B Activity and Mercury-Induced Kidney Tubule Cell Apoptosis: Implications for Renal Failure

Bruce A. Fowler1

Division of Toxicology, Agency Toxic Substances and Disease Registry, 1600 Clifton Road NE, MS F-32, Atlanta, Georgia 30333

Received October 11, 2004; accepted October 13, 2004

The first 10% of the full text of this article appears below.

The article highlighted in this issue is ‘Nuclear Factor {kappa}B Activity Determines the Sensitivity of Kidney Epithelial Cells to Apoptosis: Implications for Mercury-Induced Renal Failure,’ by Francisco J. Dieguez-Acuña, William W. Polk, Maureen E. Ellis, P. Lynne Simmonds, John V. Kushleika, and James S. Woods. This article appeared in the November issue (pp. 114–123).

The great power of understanding mechanisms of cell injury and cell death rests in providing valuable insights into how drugs and/or chemical agents may interact with target cell populations to produce clinical disease (Fowler, 1987Go). Once these insights are understood, they may . . . [Full Text of this Article]

1 For correspondence via fax: (770) 488-4178. E-mail: bxf9@cdc.gov.


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