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Toxicological Sciences 2005 83(2):205-206; doi:10.1093/toxsci/kfi047
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Toxicological Sciences vol. 83 no. 2 © Society of Toxicology 2005; all rights reserved.

TOXICOLOGICAL HIGHLIGHT

Applying Toxicogenomics in Mechanistic and Predictive Toxicology

Michael L. Cunningham*,1 and Lois Lehman-McKeeman{dagger}

* National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, and {dagger} Discovery Toxicology, Bristol Myers Squibb Company, Princeton, New Jersey, 08543

Received November 29, 2004; accepted November 29, 2004

The first 10% of the full text of this article appears below.

The advent of genomic technologies has facilitated major advances in our understanding of the molecular details of normal biology and holds the promise of providing new insights into molecular mechanisms of a variety of toxicities. However, with only a few exceptions, much of the available toxicogenomic data has to date been limited to a description of alterations in gene expression patterns and the development of hypotheses for further evaluation. The article highlighted in this issue (Sawada et al., pp. . . . [Full Text of this Article]

1 To whom correspondence should be addressed. Fax: (919) 541-4632. E-mail: cunning1@niehs.nih.gov


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