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Toxicological Sciences 2005 86(2):211-213; doi:10.1093/toxsci/kfi221
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

TOXICOLOGICAL HIGHLIGHT

Young Brains on Lead: Adult Neurological Consequences?

Nina G. Pabello* and Valerie J. Bolivar{dagger},1

* Wadsworth Center, Molecular Medicine, Albany, New York 12201 and {dagger} Wadsworth Center, Genomics Institute, Troy, New York 12180

1 To whom correspondence should be addressed. E-mail: bolivar@wadsworth.org.

Received June 8, 2005; accepted June 9, 2005

Key Words: metals; developmental neurotoxicity; neurotoxicity of metals; developmental toxicology; behavioral toxicology.

The first 10% of the full text of this article appears below.

Gilbert and colleagues examine the effect of chronic low-level lead exposure, occurring during development, on hippocampal neurogenesis and spatial learning in adulthood. The effects of lead exposure on cognitive and behavioral deficits in children leading to learning and memory impairments is well established, whereas there is little information on the long-term (adult) consequences of gestationally initiated lead exposure. One important issue that Gilbert and colleagues assess is the long-term consequences of chronic developmental low-level lead exposure in adult offspring. Secondly, Gilbert and colleagues are the first to report the effect of lead exposure on hippocampal neurogenesis.

The work by Gilbert and colleagues is intriguing, in view of the fact that this paper attempts to integrate the consequences of developmental exposure to lead, known for its ability to impair cognitive functions, such as learning and memory, with a dysfunction in adult hippocampal neurogenesis. Chronic lead exposure initiated during development . . . [Full Text of this Article]


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