Skip Navigation


ToxSci Advance Access originally published online on August 17, 2005
Toxicological Sciences 2005 88(2):307-310; doi:10.1093/toxsci/kfi277
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
88/2/307    most recent
kfi277v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Thomas, K.
Right arrow Articles by Privalle, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thomas, K.
Right arrow Articles by Privalle, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

FORUM

In Silico Methods for Evaluating Human Allergenicity to Novel Proteins: International Bioinformatics Workshop Meeting Report, 23–24 February 2005

Karluss Thomas*,1, Gary Bannon{dagger}, Susan Hefle{ddagger}, Corinne Herouet§, Michael Holsapple*, Gregory Ladics, Sue MacIntosh|| and Laura Privalle|||

* International Life Sciences Institute Health and Environmental Sciences Institute, One Thomas Circle NW, Ninth Floor, Washington, District of Columbia 20005; {dagger} Monsanto Co., 800 North Lindbergh Boulevard, St. Louis, Missouri 63167; {ddagger} Food Allergy Research and Resource Program, University of Nebraska, 255 Food Industry Building, Lincoln, Nebraska 68583; § Bayer CropScience, Regulatory Toxicology, 355 rue Doistoïevski, Sophia Antipolis, France; E.I. Dupont De Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, P.O. Box 50 1090 Elkton Road, Newark, Delaware 19714; || Bayer CropScience, P.O. Box 12014, 2 T.W. Alexander Drive, Research Triangle Park, North Carolina 27709; and ||| BASF Plant Science, 26 Davis Drive, Research Triangle Park, North Carolina 27709

Received June 14, 2005; accepted August 1, 2005

The ILSI Health and Environmental Sciences Institute (HESI) hosted an expert workshop 22–24 February 2005 in Mallorca, Spain, to review the state-of-the-science for conducting a sequence homology/bioinformatics evaluation in the context of a comprehensive allergenicity assessment for novel proteins, to obtain consensus on the value and role of bioinformatics in evaluating novel proteins, and to discuss the utility and methods of allergen-specific IgE testing in the diagnosis of food allergy. The workshop participants included over forty international experts from academia, industry, and government. The workshop was hosted by the HESI Protein Allergenicity Technical committee, which has established a long-term program whose mission is to advance the scientific understanding of the relevant parameters for characterizing the allergenic potential of novel proteins.

Key Words: allergy; antibody; antigen; IgE; food allergy; immunoglobulin.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
M. K. Selgrade, C. C. Bowman, G. S. Ladics, L. Privalle, and S. A. Laessig
Safety Assessment of Biotechnology Products for Potential Risk of Food Allergy: Implications of New Research
Toxicol. Sci., July 1, 2009; 110(1): 31 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. Thomas, G. Bannon, C. Herouet-Guicheney, G. Ladics, L. Lee, S.-I. Lee, L. Privalle, B. Ballmer-Weber, and S. Vieths
The Utility of an International Sera Bank for Use in Evaluating the Potential Human Allergenicity of Novel Proteins
Toxicol. Sci., May 1, 2007; 97(1): 27 - 31.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.