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ToxSci Advance Access originally published online on October 12, 2005
Toxicological Sciences 2006 89(2):352-360; doi:10.1093/toxsci/kfj018
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© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

REVIEW AND COMMENT

Toxicogenomics in Risk Assessment: Applications and Needs

Darrell R. Boverhof and Timothy R. Zacharewski1

Department of Biochemistry and Molecular Biology, National Food Safety and Center for Integrative Toxicology, Michigan State University, East Lansing Michigan 48824

Received August 30, 2005; accepted October 8, 2005

Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment process by providing valuable insights into toxic mechanisms of action. However, the application of these data into risk assessment practices is still in the early stages of development, and proof of principle experiments have yet to emerge. The following discusses some potential applications as well as impediments that warrant a concerted investigation from all stakeholders in order to facilitate the acceptance and subsequent incorporation of toxicogenomics into regulatory decision making.

Key Words: toxicogenomics; risk assessment.


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