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TOXICOLOGICAL HIGHLIGHT |
Site-Specific, Dose-Dependent Transitional Analysis of Toxicologic Mechanisms: The Interplay of Local Metabolic and Physicochemical Saturation
CIIT Centers for Health, Biology Division, Research Triangle Park, North Carolina 27709-2137
1 To whom correspondence should be addressed. E-mail: moss@ciit.org.
Received April 7, 2006; accepted April 10, 2006
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When animal exposures are used to assess human risk to inhaled chemicals, the animals generally receive higher dose rates over shorter periods of time. This difference in dose rate and duration of exposure, when applied to risk extrapolation, creates a key challenge: the challenge of accounting for the impact of dose and dose rate on possible transitions in mechanisms of toxicity (Slikker et al., 2004a
,b). One such transition and the related microdosimetry are the subject of this issue's highlighted article Increasing Exposure Levels Cause an Abrupt Change in the Absorption