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ToxSci Advance Access originally published online on April 18, 2006
Toxicological Sciences 2006 92(1):346; doi:10.1093/toxsci/kfj200
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Published by Oxford University Press 2006.

TO THE EDITOR

John F. Fox

National Center for Risk Assessment, Quantitative Risk Management Group, Office of Research and Development, U.S. Environmental Protection Agency (Mail Code 8623D), 1200 Pennsylvania Avenue, NW, Washington, District of Columbia 20460

E-mail: fox.john@epa.gov

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Gaylor et al. (2004)Go described a method of estimating the "zero-equivalent dose" (ZED) and a lower confidence limit for it (LZED), based upon a quadratic polynomial dose-response model. They also suggested a way to use the Environmental Protection Agency (EPA) benchmark dose software to estimate these values, which was to select the continuous-response polynomial model and to use the "Point" benchmark response (BMR) type, setting it equal to the . . . [Full Text of this Article]


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