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Toxicological Sciences 2006 94(2):235-239; doi:10.1093/toxsci/kfl122
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© The Author 2006. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for In Vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-Like Cells

Zoran Ilic*, Hyam Leffert{dagger} and Stewart Sell*,{ddagger},1

* Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208 {dagger} University of California, San Diego, Department of Pharmacology and Center for Molecular Genetics, La Jolla, California 92093-0636 {ddagger} Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, New York 12201

1 To whom correspondence should be addressed. Fax: (518) 474-0547. E-mail: sells@mail.amc.edu.

Received September 26, 2006; accepted September 27, 2006

The first 150 words of the full text of this article appear below.

The paper by Snykers et al. (2006)Go in this issue describes the in vitro differentiation of hepatocyte-like cells from mesenchymal stem cells (MSCs) that originate in the bone marrow. Although the research is directed toward the generation of a steady supply of cells for pharmacological research and testing, it could easily have even more direct clinical implications; namely, the cells derived could be used to generate a supply of functional hepatocytes for regeneration therapy following liver failure.

The methodology used in this report has been described and published before, but what sets this apart is the efficient approach to produce the desired cells. (1) Readily available, multipotent mescenchymal bone marrow–derived stem cells are used as a starting source. (2) Growth and differentiation factors are added serially to induce differentiation. (3) Several layers of confirmatory tests are applied to show that cells in the end are hepatocyte like. The results appear . . . [Full Text of this Article]

SOURCE OF CELLS

METHOD OF DIFFERENTIATION

END RESULT—HEPATOCYTES


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Z. Ilic, H. Leffert, and S. Sell
Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for In Vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-Like Cells
Toxicol. Sci., December 1, 2006; 94(2): 235 - 239.
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