ToxSci Advance Access originally published online on December 5, 2006
Toxicological Sciences 2007 96(1):115-122; doi:10.1093/toxsci/kfl179
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Dietary and In Utero Exposure to a Pentabrominated Diphenyl Ether Mixture Did Not Affect Cholinergic Parameters in the Cerebral Cortex of Ranch Mink (Mustela vison)
* Department of Natural Resource Sciences, McGill University, Macdonald Campus, Sainte-Anne-de-Bellevue, Quebec, Canada H9X 3V9
Wildlife Toxicology Division, National Wildlife Research Centre, Ottawa, Ontario, Canada K1A 0H3
Department of Public Health Sciences
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada T6G 2G3
¶ Department of Animal Science, Michigan State University, East Lansing, Michigan 48824
|| Canadian Wildlife Service, Environment Canada, Burlington, Ontario, Canada L7R 4A6
||| Community Health Program, University of Northern British Columbia, Prince George, British Columbia, Canada V2N 4Z9
1 To whom correspondence should be addressed at Community Health Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9. Fax: +001 250 960-5744. E-mail: lchan{at}unbc.ca.
Received September 25, 2006; accepted November 28, 2006
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Abstract |
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Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants that are recognized as global environmental contaminants and a potential health risk. They have been shown to elicit neurodevelopmental toxicity through disruption of the cholinergic neurotransmitter system in rodent models, but the effects of environmentally relevant exposures in wildlife species are unknown. The objective of this study was to assess the effects of the commercial pentabrominated diphenyl ether mixture DE-71 on cholinergic parameters in ranch mink (Mustela vison) following dietary exposure of adult females and in utero, lactational, and dietary exposure of their offspring. Adult females were fed diets containing 0, 0.1, 0.5, or 2.5 µg DE-71/g feed from four weeks prior to breeding through weaning of their kits at six weeks of age. A portion of the weaned kits were maintained on their respective diets through 27 weeks of age. Cholinergic parameters, including muscarinic acetylcholine receptor (mAChR) and nicotinic acetylcholine receptor (nAChR) binding, cholinesterase (ChE) activity, and acetylcholine (ACh) concentration, were assayed in the cerebral cortex, and ChE activity was measured in the plasma. In the cerebral cortex, results indicated a significant exposure-dependent increase in PBDE concentrations, but no significant effects of DE-71 on cholinergic parameters. There was a threefold increase in ChE activity in the plasma of adult females in the 2.5 µg DE-71/g feed group, but was likely due to effects on liver function. This study demonstrated that environmentally relevant exposures to DE-71 did not affect key parameters of the cholinergic neurotransmitter system in the brain of ranch mink.
Key Words: polybrominated diphenyl ether; cholinergic neurotransmitter system; congener concentration; congener profile; development; mink.
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  S. Zhang, S. J. Bursian, P. A. Martin, H. M. Chan, G. Tomy, V. P. Palace, G. J. Mayne, and J. W. Martin Reproductive and Developmental Toxicity of a Pentabrominated Diphenyl Ether Mixture, DE-71, to Ranch Mink (Mustela vison) and Hazard Assessment for Wild Mink in the Great Lakes Region Toxicol. Sci., July 1, 2009; 110(1): 107 - 116. [Abstract] [Full Text] [PDF]
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