Skip Navigation


ToxSci Advance Access originally published online on May 15, 2007
Toxicological Sciences 2007 98(2):552-560; doi:10.1093/toxsci/kfm114
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
98/2/552    most recent
kfm114v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by McDaniel, K. L.
Right arrow Articles by Moser, V. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McDaniel, K. L.
Right arrow Articles by Moser, V. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2007.

Comparison of Acute Neurobehavioral and Cholinesterase Inhibitory Effects of N-Methylcarbamates in Rat

Katherine L. McDaniel*, Stephanie Padilla*, Renée S. Marshall*, Pamela M. Phillips*, Lynda Podhorniak{dagger}, Yaorong Qian{dagger} and Virginia C. Moser*,1

* Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711 {dagger} Analytical Chemistry Branch, Office of Pesticide Programs, US Environmental Protection Agency, Fort Meade, Maryland 20755

1 To whom correspondence should be addressed at Neurotoxicology Division (MD B105-04), 109 TW Alexander Drive, USEPA, RTP, NC 27711. Fax: (919) 541-4849. E-mail: moser.ginger{at}epa.gov.

Received January 10, 2007; accepted May 1, 2007


  Abstract

While the cholinesterase-inhibiting N-methyl carbamate pesticides have been widely used, there are few studies evaluating direct functional and biochemical consequences of exposure. In the present study of the acute toxicity of seven N-methyl carbamate pesticides, we evaluated the dose-response profiles of cholinesterase (ChE) inhibition in brain and erythrocytes (RBCs) as well as motor activity (both horizontally and vertically directed) and clinical signs of overt toxicity. The chemicals tested were carbaryl, carbofuran, formetanate, methiocarb, methomyl, oxamyl, and propoxur. All were administered orally, and rats were tested in 20-min activity sessions beginning 15 min after dosing; tissues were collected immediately after activity sessions. In general, motor activity was a sensitive measure of ChE inhibition for all these carbamate pesticides, and vertical activity showed the greatest magnitude of effect at the highest doses compared to either horizontal activity or ChE inhibition. Brain and RBC ChE activities were generally affected similarly. Pearson correlation coefficients of within-subject data showed good correlation between the behavioral and biochemical end points, with brain ChE inhibition and horizontal activity showing the highest correlation values. Determination of benchmark dose levels for 10% change in each end point also revealed that these two measures produced the lowest estimates. Thus, motor activity decreases are highly predictive of ChE inhibition for N-methyl carbamates, and vice versa.

Key Words: N-methyl carbamates; neurotoxicity; motor activity; cholinesterase; rats.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.