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Toxicological Sciences 2007 99(1):1-2; doi:10.1093/toxsci/kfm117
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Mixed Messages

Kim Boekelheide1

Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912

1 To whom correspondence should be addressed. Fax: (401)863-9008. E-mail: kim_boekelheide@brown.edu.

Received May 7, 2007; accepted May 8, 2007

Key Words: mixtures; endocrine disruptors; developmental toxicity; prenatal; reproductive tract; male; testis.

The first 10% of the full text of this article appears below.

Our understanding of mixed exposures is still very much in its infancy, even though the vast majority of environmental exposures are mixed exposures. The basic reason for this lack of understanding is the huge investment needed to describe the dose-response behavior of the single components before a mixture can be interpreted as the net result of their interactions.

An alternative approach to understanding mixed exposures is simply to treat the mixture as the exposure and evaluate the effects of the mixture as a whole without trying to parse out the contributions of the components. This approach is certainly useful for relatively stable formulations produced in large amounts; you might think of gasoline as an example of such a product, but I bet that the differences among crude oil sources and refineries make . . . [Full Text of this Article]

DEVELOPING THE TOXICOLOGICAL SCIENCE OF MIXTURES IS NOT GOING TO BE EASY OR FAST OR CHEAP

DEVELOPING THE TOXICOLOGICAL SCIENCE OF MIXTURES IS NOT GOING TO BE EASY OR FAST OR CHEAP ... BUT YOU HAVE TO START SOMEWHERE


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