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ToxSci Advance Access published online on March 7, 2003
Toxicological Sciences, doi:10.1093/toxsci/kfg038
Toxicological Sciences © Society of Toxicology 2003; all rights reserved
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Received November 7, 2002; accepted December 31, 2002
© 2003 Society of Toxicology

Safety Evaluation

The Mutagenic Potential of the Furylethylene Derivative 2-Furyl-1-Nitroethene in the Mouse Bone Marrow Micronucleus Test

Jorge I. González Borroto 1, Amadeu Creus 2, Ricard Marcos 2*, Ricard Mollà 3, Jorge Zapatero 3

1 Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain; Centro de Investigación y Desarrollo Aplicado, Cida s.a.l.,08130 Santa Perpètua de Mogoda, Barcelona, Spain
2 Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
3 Centro de Investigación y Desarrollo Aplicado, Cida s.a.l.,08130 Santa Perpètua de Mogoda, Barcelona, Spain

* To whom correspondence should be addressed. E-mail: ricard.marcos{at}uab.es.


  Abstract

The compound 2-furyl-1-nitroethene (G-0) has been tested to determine its ability to induce clastogenic or aneugenic effects in vivo, through the induction of micronucleated polychromatic erythrocytes (MNPCE) in mouse bone marrow. Groups of five CD-1 male mice were administered once intraperitoneally at a dose range of 5-20 mg/kg and bone marrow was sampled 24 and 48 h after the treatment. G-0 was dissolved in corn oil, thus a vehicle control group received only corn oil at 10 ml/kg. The positive control group was administered with cyclophosphamide (40 mg/kg). All animals dosed with the highest concentration of the test agent (20 mg/kg) showed evident clinical symptoms of toxicity. Although evidences of bone marrow toxicity were observed, no statistically significant increases in the incidence of MNPCE over the vehicle control group were observed at any sampling time with any of the assayed doses of the G-0 compound. Cyclophosphamide treatment increased the incidence of MNPCE in all treated animals, demonstrating the sensitivity of the assay in the conditions it was carried out. From the results obtained, it is concluded that the test agent G-0 is neither clastogenic nor aneugenic in the erythrocytes from the bone marrow of treated mice at the doses tested.

Micronucleus assay, Mice, Furylethylenes, Polychromatic erythrocytes, Bone marrow .


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