Skip Navigation



ToxSci Advance Access published online on April 15, 2003
Toxicological Sciences, doi:10.1093/toxsci/kfg043
Toxicological Sciences © Society of Toxicology 2003; all rights reserved
This Article
Right arrow Advance Access manuscript (PDF) Freely available
Right arrow All Versions of this Article:
73/1/141    most recent
kfg043v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Picard, A.
Right arrow Articles by Ciapa, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Picard, A.
Right arrow Articles by Ciapa, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Received September 23, 2002; accepted January 9, 2003
© 2003 Society of Toxicology

Reproductive and Developmental Toxicology

Effect of Organochlorine Pesticides on Maturation of Starfish and Mouse Oocytes

André Picard 1, Golbahar Palavan 2, Stéphanie Robert 3, Danielle Pesando 3, Brigitte Ciapa 2*

1 Laboratoire Arago, BP 44, Banyuls sur mer F-66651 cedex, France
2 Laboratoire de Biologie du Développement, UMR 7622 CNRS, Université Paris 6, Bât C 5ème étage, Boîte 24, 75252 Paris cedex 05
3 Laboratoire Réponses des Organismes aux Stress de l'Environnement, UMR INRA-UNSA 1112, Faculté des Sciences, Parc Valrose, BP 71, 06108 Nice cedex, France

* To whom correspondence should be addressed. E-mail: ciapa{at}snv.jussieu.fr.


  Abstract

Methoxychlor, lindane and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.

pesticide, methoxychlor, dieldrin, lindane, starfish, mouse, maturation, fertilization, meiosis .


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum Reprod UpdateHome page
E. V. Younglai, A. C. Holloway, and W. G. Foster
Environmental and occupational factors affecting fertility and IVF success
Hum. Reprod. Update, January 1, 2005; 11(1): 43 - 57.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.