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ToxSci Advance Access published online on May 28, 2003
Toxicological Sciences, doi:10.1093/toxsci/kfg140
Toxicological Sciences © Society of Toxicology 2003; all rights reserved
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Received May 2, 2003; accepted May 5, 2003
© 2003 Society of Toxicology

Toxicological Highlight

The Mitochondrial Benzodiazepine Receptor as a Potential Target Protein for Drug Development: Demonstration of Functional Significance with Cell Lines Exhibiting Differential Expression of Bcl-2

Lawrence H. Lash 1*

1 Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201

* To whom correspondence should be addressed. E-mail: l.h.lash{at}wayne.edu.


  Abstract

The article highlighted in this issue is "Reversal of Bcl-2 Mediated Resistance of the EW36 Human B-Cell Lymphoma Cell Line to Arsenite and Pesticide-Induced Apoptosis by PK11195, a Ligand of the Mitochondrial Benzodiazepine Receptor," by Donna E. Muscarella, Kerry A. O'Brien, Ann T. Lemley, and Stephen E. Bloom from Cornell University in Ithaca, NY. The following, brief review summarizes their findings, highlights the novel biological model and experimental approach used, and explores potential mechanistic and therapeutic implications of these findings.


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