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ToxSci Advance Access first published online on January 21, 2004
This version published online on March 19, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh070
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
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Received November 10, 2003; accepted December 3, 2003
© 2004 Society of Toxicology

Immunotoxicology

Motorcycle Exhaust Particles Induced Airway Allergic Inflammation on BALB/c Mice

Chen-Chen Lee 1, Jiunn-Wang Liao 2, and Jaw-Jou Kang 1*

1 Institute of Toxicology, College of Medicine, National Taiwan University, 1 Jen-Ai Rd, Section 1, Taipei, Taiwan, ROC
2 Department of Applied Toxicology, Taiwan Agricultural Chemicals and Toxic Substances Research Institute, Taichung, Taiwan, ROC.

* To whom correspondence should be addressed. E-mail: jjkang{at}ha.mc.ntu.edu.tw.


  Abstract

Large survey and experiments have reported that environmental pollutants from fossil fuel combustion would cause immune system deleterious by enhancement of allergic reaction and damage to respiratory tract. In this study, we investigated the effect of motorcycle exhaust particles (MEP), a major pollutant in Taiwan urban area, on airway allergic reaction in laboratory animals. BALB/c mice were intratracheal instillation with MEP once every two weeks for three times. We found MEP would induce airway inflammation characterized by infiltration of eosinophils, neutrophils, lymphocytes, and macrophages in bronchoalveolar lavage fluid (BALF) and caused inflammation of lung. In addition, MEP treatment enhanced BALF IL-4, IFN-{gamma} cytokine and serum IgE production and induced airway hyperresponsiveness. The benzene-extracted fraction induced airway inflammation characterized by infiltration of eosinophils and neutrophils, increase of BALF IL-4 production and serum IgE, and induction of airway hyperresponsiveness as seen with MEP.

Key Words: airway hyperresponsiveness, airway allergic inflammation, asthma, IgE, intratracheal instillation, motorcycle exhaust particles .


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