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ToxSci Advance Access published online on May 12, 2004
Toxicological Sciences, doi:10.1093/toxsci/kfh136
Toxicological Sciences © Society of Toxicology 2004; all rights reserved
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Received April 5, 2004
Accepted April 6, 2004

Toxicological Highlight

2,3,7,8-Tetrachloro-p-dioxin (TCDD) and Long Term Immunologic Memory

David H. Sherr 1*

1 Department of Environmental Health, Boston University School of Public Health, 715 Albany Street (R-408), Boston, Massachusetts, 02118

* To whom correspondence should be addressed. E-mail: dsherr{at}bu.edu.


  Abstract

The highlighted article by B. Paige Lawrence and Beth Vorderstrasse addresses an oft forgotten aspect of immunotoxicity, the effects of environmental toxins on immunologic memory. Here, the authors take a step towards filling that information gap by evaluating the effects of a prototypic environmental toxin, 2,3,7,8-tetrachloro-p-dioxin (TCDD), on memory responses to a real-world pathogen, influenza A virus, presented to an animal model in a physiologically relevant manner. Multiple outcomes are evaluated, the vast majority of which suggest important and long-term TCDD-induced changes in the immune system after both primary and secondary exposure to this pathogen. The implications of these studies with regard to the immuno-competence of TCDD-exposed individuals are far reaching.


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